Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-234.
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The articles featured in the Blood Flashback series were selected and the commentaries written by the Blood Editors. Complete versions of all the articles in the series, commemorating the journal’s 70th-anniversary year, can be found on the Blood Web site at www.bloodjournal.org/collection/blood-flashback. Leading the Way in Hematology For personal use only. on August 31, 2016. by guest www.bloodjournal.org From
منابع مشابه
Advances in the clinical staging of chronic lymphocytic leukemia.
Featured Article: Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood 1975;46:219 –34. Before publication of this article, clinicians treating chronic lymphocytic leukemia (CLL) experienced a high level of frustration because of the vast heterogeneity in the clinical courses of patients with CLL. After their initial diagno...
متن کاملClinical staging of chronic lymphocytic leukemia.
A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and s...
متن کاملCorrelation of total body potassium and leukemic cell mass in patients with chronic lymphocytic leukemia.
Total body leukemic mass in patients with chronic lymphocytic leukemia (CLL) was measured by quantitation of total body potassium (TBK) with a whole-body counter. In addition, the predicted normal total body potassium (Kp) for each patient was calculated from an empirically derived relationship involving height, weight, age, and sex. Both the absolute TBK and the relative excess of total body p...
متن کاملBlimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia
Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreate...
متن کاملCD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized with poor effector functions and the expression of multiple inhibitory receptors. Objective: To inve...
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ورودعنوان ژورنال:
- Blood
دوره 128 17 شماره
صفحات -
تاریخ انتشار 2016